Wednesday, October 29, 2008

Herbal asthma remedies

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To do this research, Neelamegham's lab uses systems biology, a mathematical and experimental approach that focuses on whole systems of complex biological functions and interactions instead of studying individual units, such as a single gene or protein, in isolation.
'Systems biology is well-suited to this research because it helps us develop the mathematical concepts to enable us to influence and enhance our understanding of how the glycome functions,' said Neelamegham. 'This then produces clues on how we might manipulate the adhesivity of white blood cells to the blood vessel wall.'
Glycans are carbohydrate molecules that mediate the microscopic interactions between white blood cells and blood vessel walls. These interactions play a major role in painful and debilitating inflammatory medical conditions such as asthma, psoriasis, Crohn's disease, reperfusion injury and other cardiovascular ailments.
In a recent paper in The FASEB Journal, the UB researchers describe one of the first studies to take a systems approach to the study of cellular glycosylation, the modification process that is responsible for the attachment of sugar structures to protein and lipid scaffolds. Such biochemical modifications are critical to diverse biological processes, including cell/organ development, immunity and cell adhesion


With six Stalevo dosage strengths, physicians have more prescribing flexibility, which may enable more individualized approaches to treating people with Parkinson's disease.'
About Stalevo
Stalevo is approved to substitute immediate-release carbidopa/levodopa and entacapone previously administered as individual products, or to replace immediate-release carbidopa/levodopa therapy, without entacapone, in certain Parkinson's disease patients who are experiencing the signs and symptoms of end-of-dose 'wearing off'.
Stalevo, originated and manufactured by Orion Corporation, was approved by the U.S. Food and Drug Administration (FDA) in June 2003 and is marketed in the United States by Novartis Pharmaceuticals Corporation.
Important Safety Information
The most common side effects of Stalevo are unwanted or uncontrollable movements (known as dyskinesia), nausea, diarrhea, excessive muscle movements (known as hyperkinesia), harmless discoloration of urine, sweat and/or saliva, diminished or slow movements (known as hypokinesia), abdominal pain, dizziness, constipation, fatigue, pain, and hallucinations. Some of the more serious side effects may include severe diarrhea, severe dyskinesia, hallucinations, other mental disturbances, orthostatic hypotension (low blood pressure), rhabdomyolysis (a muscle disease), and symptoms resembling neuroleptic malignant syndrome (a condition characterized by fever and muscle stiffness).
Be careful using Stalevo if you have severe heart or lung disease, asthma, renal, hepatic, or endocrine disease, or a history of heart attacks or ulcers. Do not take Stalevo if you have glaucoma, melanoma, or other related medical disorders.
Drugs broken down by the COMT enzyme (e.g., isoproterenol, epinephrine) should be used with caution when taking Stalevo. If you take a nonselective monoamine oxidase (MAO) inhibitor, you should not take Stalevo. Stalevo should not be taken with selegiline at doses higher than 10 mg/day



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