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The goal here is to develop conventional small-molecule drugs that block a specific marker inside cells called the PI3 kinase pathway. This pathway's job is to stimulate a bunch of cell processes like proliferation, growth, migration, metabolism, and cell survival. Research has shown that when they are switched into an overactive mode, they can play a key role in diseases like blood cancers and autoimmune diseases like asthma and rheumatoid arthritis. The tricky part is that these same functions can be essential for healthy, normal cells-so a drug that completely knocks out all varieties of this pathway could have serious side effects.
Calistoga thinks its secret sauce is biology that says if you block a specific type of PI3 kinase, called the delta isoform (which only appears on certain blood cells), then you can have the therapeutic benefit without potential for side effects from drugs that block a broader spectrum of PI3 kinase types.
The PI3 kinase pathway is a hot topic in the biotech industry, because of the role it appears to play in many cancers, and has generated interest from a number of companies. The list includes Swiss drug giant Novartis, South San Francisco-based Exelixis, and San Diego-based Intellikine, Gallatin says.
What makes Calistoga different is its specific focus on the delta form of PI3 kinase, and that it is the first group to take such a targeted drug into clinical trials, he says

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